Regulation of protein degradation, protein–protein interactions, protein This modification has a variety of biological roles, including Proteins in humans and 50–70% in yeast 1– 4. Protein covalent modifications in eukaryotes, occurring in 80–90% of soluble N-α-terminal acetylation (Nt-acetylation) is one of the most common These findings indicate that NatD is a crucial epigenetic modulator of cell invasion ![]() Upregulated in primary human lung cancer tissues where its expression levelĬorrelates with Slug expression, enhanced invasiveness, and poor clinical outcomes. To suppress Slug transcription to inhibit EMT. H4 in lung cancer cells, resulting in increased H4S1ph and epigenetic reprogramming Histone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and thatĭownregulation of Nt-acetylation of histone H4 facilitates CK2α binding to histone Transcription factor Slug, a key regulator of EMT. Transition (EMT) of lung cancer cells by directly repressing the expression of Depletion of NatD suppresses the epithelial-to-mesenchymal ![]() That NatD promotes the migratory and invasive capabilities of lung cancer cells in ![]() (Nt-acetylation) of histone H4 known to be involved in cell growth. N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation
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